Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 22 - Jul 27
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
PINK1 Recombinant Rabbit mAb (S-3135-28)Product Specification Host Rabbit Antigen PINK1 Synonyms Serine threonine protein kinase PINK1, mitochondrial; BRPK; PTEN induced putative kinase protein 1 Immunogen Synthetic Peptide Location Cytoplasm, Mitochondrion Accession Q9BXM7 Clone Number S 3135 28 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample CCCP treated HeLa, CCCP treated HEK 293 Purification Protein A Concentration 2 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | PINK1 |
| Synonyms | Serine/threonine-protein kinase PINK1, mitochondrial; BRPK; PTEN-induced putative kinase protein 1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Mitochondrion |
| Accession | Q9BXM7 |
| Clone Number | S-3135-28 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | CCCP treated HeLa, CCCP treated HEK-293 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
PINK1 (PTEN-induced putative kinase 1) is a serine/threonine kinase primarily localized to mitochondria that serves as a critical sensor for mitochondrial quality control through the PINK1/Parkin mitophagy pathway; upon mitochondrial damage, PINK1 stabilizes on the outer mitochondrial membrane and phosphorylates both ubiquitin and the E3 ubiquitin ligase Parkin, initiating the selective autophagic clearance of dysfunctional mitochondria, while loss-of-function mutations in the PINK1 gene are linked to autosomal recessive early-onset Parkinson's disease, highlighting its essential role in neuronal survival and protection against neurodegeneration.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy