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Description
Human IL-21 Serum & Plasma Onestep ELISA KitProduct Specification Antigen IL 21 Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 1. 3% Inter assay: 1. 9% Sample type Serum; Plasma Assay type Sandwich (quantitative) Sensitivity 151. 233pg mL Range 219. 5 pg mL 2500 pg mL Recovery Serum: 113% EDTA Plasma: 108% Assay time 60 minutes
Product Specification
| Antigen | IL-21 |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 1.3%； Inter-assay: 1.9% |
| Sample type | Serum; Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 151.233pg/mL |
| Range | 219.5 pg/mL – 2500 pg/mL |
| Recovery | Serum: 113% EDTA Plasma: 108% |
| Assay time | 60 minutes |
| Species reactivity | Hu |
Background
Interleukin-21 (IL-21) is a multifunctional type I cytokine primarily secreted by activated CD4+ T cells, including T follicular helper (Tfh) and Th17 subsets. It signals through a receptor complex consisting of a unique IL-21 receptor (IL-21R) and the common γ-chain, activating JAK-STAT, MAPK, and PI3K pathways. IL-21 plays a central role in modulating both adaptive and innate immune responses: it critically regulates B cell differentiation, class-switching, and antibody production; enhances the activity and expansion of CD8+ cytotoxic T cells and NK cells; and influences CD4+ T cell fate. Due to these potent immunoregulatory functions, IL-21 is deeply involved in the pathogenesis of autoimmune diseases (e.g., systemic lupus erythematosus, rheumatoid arthritis) and promotes anti-tumor immunity. Consequently, the IL-21 pathway is a promising therapeutic target, with strategies ranging from recombinant IL-21 as a potential immunostimulant in oncology to blocking antibodies for treating autoimmune and inflammatory conditions.
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