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Description
Invivo Anti-Mouse GITR Recombinant mAbProduct Specification Host Rat Antigen GITR Synonyms Tumor necrosis factor receptor superfamily member 18; Glucocorticoid induced TNFR related protein; CD357; Gitr; Tnfrsf18 Location Cell membrane Accession O35714 Clone Number S 3837 Antibody Type Rat mAb Application FCM, in vivo GITR stimulation Purification Protein G Concentration 5 mg ml Purity >95% (Determined by SDS PAGE) Endotoxin <1EU mg Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rat |
| Antigen | GITR |
| Synonyms | Tumor necrosis factor receptor superfamily member 18; Glucocorticoid-induced TNFR-related protein; CD357; Gitr; Tnfrsf18 |
| Location | Cell membrane |
| Accession | O35714 |
| Clone Number | S-3837 |
| Antibody Type | Rat mAb |
| Application | FCM, in vivo GITR stimulation |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% (Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
GITR (glucocorticoid-induced TNF receptor, TNFRSF18/CD357) is a cell-surface receptor of the TNF-receptor superfamily that is constitutively expressed at high levels on regulatory T cells (Tregs) and is rapidly up-regulated on activated CD4⁺/CD8⁺ T cells and NK cells; engagement of GITR by its ligand GITRL (TNFSF18) on antigen-presenting cells delivers a costimulatory signal that activates the NF-κB pathway, enhances IL-2 and IFN-γ production, up-regulates the anti-apoptotic protein Bcl-xL, and thereby amplifies effector T-cell proliferation, cytokine secretion and cytotoxicity while transiently destabilizing FoxP3 and the suppressive function of Tregs, making GITR an attractive target for cancer immunotherapy.
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4.9 ★★★★★
Based on 1844 reviews
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Product Reviews
★★★★★ 5
Still squeaking after all these days!
Size: Jumbo, Style: Beef
My power chewer GSPs usually wreck all "tough" toys in less than an hour, especially if they squeak. These seem pricey but I can say it's held up really well. After about three weeks, it's still hanging in there! The stripes are worn off but the squeaker still squeaks and that's what it's all about.
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Reviewed in the United States on May 15, 2026
★★★★★ 5
Long lasting scent and has not been destroyed by my heavy chewer.
Size: Jumbo, Style: Bacon
My medium puppy loves this ball. She already has the smaller size but appears to enjoy the challenge of catching the large one. An added benefit is it's easier for me to win it back when we fight (play fighting) for it.
The scent really lasts. I've had the smaller version for a few months and the scent is still there. Does it really smell like bacon? Not to my nose but the puppy thinks it's awesome.
The ball itself is really tough. The pup can destroy a tennis ball in a day. Except for a few teeth marks these balls are holding together great.
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Reviewed in the United States on June 10, 2026
★★★★★ 5
Worth every penny—my beagle is obsessed
Size: Medium, Style: Cheddar Cheese, Size: Medium, Style: Cheddar Cheese
No dog toy is indestructible if you have a hound or a pit. I happen to have a combination of both. This toy is the best $12 you could possibly spend for a dog that likes to “kill” their toys. The only reason I’m buying more is because I keep losing them.
My dog is a rescue. She’s half beagle, a quarter boxer, and a quarter pit bull. She’s a tiny fire-cracker and I lover her to pieces. And she loves tennis balls to pieces. Literally.
She adores tennis balls, squeaky toys, and food. She will absolutely try to surgically extract the squeaker from any toy she gets because she has a high prey-drive. These balls last usually at least a week before she manages to dislodge the squeaker or puncture the squeaking mechanism, but I still have one I got about six months ago that has the paint worn off and it still squeaks.
This ball literally has everything. It squeaks, it bounces pretty high, it looks like a real tennis ball so my girl recognizes them as “toy” immediately, and they smell good.
These balls in particular last forever. I got her a can of regular tennis balls and she had them in four pieces within 10 minutes or less, which is not healthy for her because she likes to eat the pieces. For this dog toy, I have never seen her crack it. She’s pushed the squeaker inside of exactly one of them so far, and it stayed inside the ball. Much safer than a toy that she can possibly ingest.
The toys come in several colors, but it’s not just to make them look cute and colorful. The colors correspond to flavors, as each of the balls has a different scent. I’ve sniffed them and noticed there’s a mild food smell beneath the rubber scent. I can tell that dogs really do get a kick out of the “flavors.”
I’ve taken these to the dog park and all the dogs want the Playology tennis ball, even if we have other generic balls flying around. My dog even has favorites. We have a muscle-head pit bull/staffy mix at the park who is a giant meat-ball. He got his hands on one of these and he wasn’t even able to break it open for at least 20 minutes of deliberate chewing.
My girl’s favorite “flavor” for a long time was beef (the red one). The blue “peanut butter” flavor is the easiest one to find in stores. She was obsessed with a purple one for a while, apparently it was bacon flavor. I couldn’t find that one! I saw that Amazon has an orange “cheese” flavor and knew she’d love it. She’s obsessed.
I really wanted to leave this review to convince people to invest in this product. Your dog will be so happy, and this company made something great.
I’m worried because I went on their website yesterday and they had only one or two colors available. I don’t want them to stop making this amazing toy. I hope they don’t lose business because their product is TOO durable!! If they make more flavors, or maybe make some multi-dog (tug ropes?) or similar, I’ll definitely continue to be a customer. Please keep making these awesome tennis balls!
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Reviewed in the United States on January 13, 2025
★★★★★ 5
Not Squeakable for Mini/Toy Aussies
Size: Medium (VALUE 2-Pack), Style: Chicken
Very durable and good squeaker. However, too large and hard for my Mini Aussies to squeak. My Aussies love their squeaky toys, unfortunately not this one.
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Reviewed in the United States on May 1, 2026
★★★★★ 4
Not indestructable, but very sturdy
Size: Medium, Style: Beef
I have recently been blessed (and cursed) with my first Super Chewer dog, a year old Australian Shepherd. She will chew herself out of boredom, so it's imperative we always have sturdy toys readily available for her, preferably in every room.
Playology and Kong by and large have been the best toys we can find for her. Kong has a very good rubber ball, bone, and ring that have held up spectacularly (no noticeable damage after months of use, except maybe some pin-prick teeth marks). Dogs need a wide range of textures though for enrichment, so we've been dabbling with the Playology line (the tire, plush bone, dry-tech rope), including this ball.
The scent factor is definitely interesting. Most people know Playology for the peanut butter scents, so I was very excited to find a multitude of flavors available on Amazon, especially with the different scents clearly labeled. I choose the red or beef flavored since the only two in the medium size in stock at the time were beef and sweet potato. The scent is indeed noticeable to humans, but it's not too strong or overwhelming on its own (walking down the Playology aisle in Petsmart can be overwhelming though since they have dozens of dozens of scented toys, much like going down a candle aisle).
I can't speak for the dog on how she feels about the scent, but she took to the ball immediately, same as the normal peanut butter ones we get. The medium size is pretty much perfect for her (she's just under 50lbs). It's got decent bounce for playing fetch in the house, but not so bouncy that we're afraid to use it in the house. It's got a decent density to it as well that adds to the sturdiness.
The biggest issue is the squeaker. It's not an obnoxious squeaker by any means, and the dog enjoys it very much. However, when you put a squeaker in any toy, it reduces the density and creates a weak spot dogs can exploit. She did good with the ball at first and was able to sit and chew on it for minutes as a time without doing any real damage (her teeth leave lots of pin-prick teeth marks, but they don't do any real damage to the ball, just superficial marks).
Aussies are considered incredibly smart though, and it didn't take her long to learn she could rip out the bottom of the ball where the squeaker is sealed inside to tear the squeaker out, thus ripping the squeaker apart and compromising the structural integrity of the ball. We're debating if we want to toss the ball in the trash or attempt letting her play with it in a supervised session without the squeaker to see if it is safe.
So, overall, this is a very tough ball. It does accumulate teeth marks that are essentially harmless, but there is a weak spot in the seam where the squeaker is inserted, which means this is not indestructible. It is by and large a great ball for fetch and likely won't ever be destroyed unless a dog is left with it long enough to chew a hole through that squeaker seam. Playology balls are pretty costly though, so the risk of it becoming unusable once the squeaker is ripped out is a bit off-putting. The bright side is that if you monitor your dog, you can likely get several weeks or months of use out of the ball; just no unsupervised play sessions.
7/10, durable, bouncy, and the scent keeps the dog interested, but the ball is not good unsupervised as it can be destroyed if the squeaker is ripped out. We will continue to buy Playology toys, but we will likely not buy too many of these balls until a more durable one (maybe without a squeaker) is released.
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Reviewed in the United States on March 20, 2022