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Description
Rat Anti-Mouse LPAM-1 Antibody (S-3206)Product Specification Host Rat Antigen LPAM 1 Location Cell membrane Accession P26011 Clone Number S 3206 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied Dilution application
Product Specification
| Host | Rat |
| Antigen | LPAM-1 |
| Location | Cell membrane |
| Accession | P26011 |
| Clone Number | S-3206 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
LPAM-1 (Lymphocyte Peyer’s patch Adhesion Molecule-1), also designated integrin α4β7, is a 150/130 kDa heterodimeric surface glycoprotein of the integrin immunoglobulin superfamily that is constitutively expressed on naive T and B cells, up-regulated on gut-homing memory CD4⁺ T cells and IgA-secreting plasma cells by retinoic acid, and serves as the principal homing receptor mediating rolling and firm adhesion of these leukocytes to mucosal vascular addressin MAdCAM-1 on high endothelial venules of Peyer’s patches and intestinal lamina propria, thereby orchestrating their trans-endothelial migration into gut-associated lymphoid tissues during both steady-state immune surveillance and inflammatory bowel diseases, and can also engage VCAM-1 and fibronectin to support lymphocyte trafficking and retention.
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