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Description
Lymphocyte antigen 75/CD205 Recombinant Rabbit mAb (S-2707-25)Product Specification Host Rabbit Antigen CD205 Synonyms Lymphocyte antigen 75; Ly 75; C type lectin domain family 13 member B; DEC 205; gp200 MR6; CLEC13B; LY75 Immunogen Recombinant Protein Location Membrane Accession O60449 Clone Number S 2707 25 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample THP 1, Daudi Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | CD205 |
| Synonyms | Lymphocyte antigen 75; Ly-75; C-type lectin domain family 13 member B; DEC-205; gp200-MR6; CLEC13B; LY75 |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | O60449 |
| Clone Number | S-2707-25 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | THP-1, Daudi |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
Background
CD205, also known as DEC205 or LY75, is a ~205 kDa type I transmembrane glycoprotein belonging to the macrophage mannose receptor family of C-type lectins; it contains an N-terminal cysteine-rich domain, a fibronectin type II repeat, ten tandem C-type lectin-like carbohydrate-recognition domains, a single transmembrane segment and a short cytoplasmic tail harboring the tyrosine-based “FERN” and “DIEEV” endosomal sorting motifs that drive constitutive clathrin-mediated internalization and recycling to late endosomes/MHC class II compartments. Predominantly expressed on CD8α⁺ dendritic cells, thymic epithelial cells and certain B subsets, CD205 functions as a pattern-recognition receptor that binds apoptotic/necrotic cells, selected glycoproteins and CpG-rich nucleic acids, enabling efficient capture, processing and cross-presentation of antigens for initiation of CD8⁺ T-cell immunity; this property has made it a premier target for receptor-directed vaccination strategies in which antigens are fused to anti-CD205 antibodies to elicit potent, antigen-specific tolerance or protective responses. In addition, CD205 participates in peripheral T-cell deletion, central tolerance through negative selection in the thymus, and has been implicated in autoimmune diseases, tumor immunosurveillance and metastasis, with its expression levels correlating with prognosis in several cancers, thereby serving as both a biomarker and a therapeutic gateway in immunotherapy.
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4.2 ★★★★★
Based on 1516 reviews
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Product Reviews
★★★★★ 4
Great if you're average height.
Color: Black
Comfortable for the price. The seat could be a bit better, but for a budget friendly ergonomic chair, it's well made and has helped a lot with my back pain caused by my previous desk chair.
Assembly wasn't terribly difficult, though I did have one screw with damaged threads. Luckily they ship spare screws in the kit, so that was a non-issue.
Rollers work great on my small rug and hard flooring and don't tend to tangle cords or cables too much.
Size wise, works great for my frame (5 ft 6 in) but for someone more than a few inches taller than myself, you should probably look at another chair.
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Reviewed in the United States on September 4, 2025
★★★★★ 5
Great chair
Color: Black
I am very happy with my purchase. Easy to assemble but be aware your drill bits included with your set won't fit their screws. However, you can get a fair bit done with the drill and then use tool included to adjust. Super comfortable and exactly the right height for my desk. Highly recommend for quality exceeding price point.
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Reviewed in the United States on May 9, 2026
★★★★★ 1
Review from an "actual" tall person who doesn't weigh 400 pounds.
Color: Black
I recommend this chair.
Firstly, I looked at least dozens of chairs and nearly every review in trying to select a chair. I didn't want to spend $200.
It's confusing because everyone's idea of perfect is of course subjective. One thing, What is tall? I'm 6'6" I think that's pretty tall. Others feel that 6'0" is tall. LOL In the listing, it shows this chair is good for a 6'5" person which I think is pretty accurate. I weigh about 210 pounds and the padding is just fine. One thing I would push manufacturers to do would be to give accurate measurements. Seat height low and high. Back support height. Head rest added to back height etc.! Maybe actual human measurements that the chair is geared toward. Nice to know that 400 lbs is cool but that doesn't tell me much.
My primary goal was to find a chair I could sleep in because I recently had a
back injury and sleeping on my bed, while fine, resulted in intense pain trying
to get up in the morning. We'll see what happens but the headrest reaches my head
which was goal one.
The lumbar fits so I don't need to use cushions and pads etc. I found the upper
position of the support to be right for me and it's super comfortable. Plus number
two.
The raised height of the chair fits my long legs (inseam 36") Plus three.
I wanted adjustable arm rests but this one doesn't have that. No biggie, for me the height of the arm rests is pretty much just right. It might be a little high for some.
The back leaning adjustment doesn't lock except for upright. Locking upright is good, and leaning back - for me - doesn't really need to lock.
Being an actual tall person made me really skeptical. I'm relieved that I won't have to take it apart to return it. The assembly was straight forward and pretty easy though I'd suggest not really tightening the arms snugly before getting the back squared away - the alignment is easier if you do that.
I got the chair for $109 with 21% off. It's slightly wobbly yet feels pretty well made. It rolls well enough.
I'm quite satisfied with the purchase and I'll come back if there are updates.
Edit one. I've had it a week now and found I couldn't sleep in it. I think it would be better if the back could recline separately from the seat. There might also be figuring out a way to support my legs due to the back and seat reclining together rather than separately. Two. I kind of wish more now that the arms were adjustable for height and tilt if that makes sense. I have a bar stool next to me on the right in front of my desk that is the right height to relax my right arm while reaching my mouse on the desk so that's my work around there. Three. The casters are kind of basic and don't roll as easily on the floor matt as my former second hand chair - they would probably be fine on a hard surface. I'll probably switch them out. Four: The lumbar support, while mostly in the right place is unpadded and creates kind of a hard spot there. I've re-introduced my lumbar support pillows for comfort there.
All in all, I'm still happy with the $100 purchase. In my experience, being pretty tall always comes with compromise and these notes are not deal breakers for me.
Yea, It can always be more perfect but unless you're in a showroom test driving and willing to spend $300? Right.
UPDATE: I'm really not satisfied with this chair and in fact, I wish I hadn't bought it. Firstly, the pneumatic post that the chair part connects with is wobbly depending on which way it is facing according to which way the legs are aligned. It's like a poor fit and I'm pretty mechanically inclined.
Second and also important. The lock to keep it upright and inclined only worked for a few weeks. For a while, you had to mess with it to engage the upright position. It no longer works.
Worse than that, the lumbar support pad disconnected with the chair and is now floating and after only a month or so, the remaining supports for the Lumbar rest have dug into the fabric on the back of the chair creating holes in the back's fabric. I've tried but there is no way to reconnect that bit without removing the back's fabric as far as I can see.
I'm taking this down to one star for sure. Poor design? Poor manufacturing? Yea. I wouldn't suggest this chair to anyone. If the company comes up with a solution, I'll continue my review.
As for now. Not a recommendation.
Update: Not impressed and kind of crappy. Mentioned is that the so called lumbar thingy disconnected and is unusable. I've got my own pad which seems to help. Also, it's wiggly where the chair connects to the base. Months later, I might toss it and go back to the chair I bought locally and second hand.
Don't buy this chair!
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Reviewed in the United States on March 20, 2025
★★★★★ 5
Great Instructions, Straightforward Assembly
Color: Black
I just received this chair today, so my product review is mostly on the packaging, instructions, and assembly.
The product was well-packaged, and it was obvious when I unboxed it that a lot of care and thought went into packing it in the most efficient way that would also protect the parts. I was positively impressed with the packaging.
I was also incredibly impressed with the instructions and assembly process. I am used to cheaper products where the parts only half fit or important components are missing, or where the instructions were confusing and unclear. This chair's instruction manual was very clear and concise. The diagrams were easy to understand and neat. The screws came labeled and separated and also included the scew types and sizes/lengths, which is handy in case you need to pick up extras at a store somewhere. But they also included one extra of each type of screw, washer, and cover, which I appreciated during assembly. (I didn't find myself worrying what would happen if I dropped a screw, which is something I would normally be distsracted by while working.)
The only things I would take points off for were these:
1. The instructions said the chair came with gloves for assembly, but no gloves were included. That was fine with me, but why mention them if you won't include them? The instructions even later say not to use the chair if not all components were present...but all the important ones were, so I assembled it without gloves (as I probably would have done anyway, since it was for me and not another person).
2. It matters which side of the seat is the front, but the sticker was confusing. The instructions show a sticker placed on the side that is the front, and that is where my sticker was placed. However, the sticker says "FRONT" and has an arrow pointing somewhere. In the instructions this arrow pointed to the front. On my seat, however, the arrow pointed to the back. So am I supposed to believe the sticker placement (it was diagonal, so it looked haphazardly slapped on) or the arrow? On that particular step the piece you are screwing into the seat can fit both ways, but thankfully there is a later step where it becomes obvious which side is the front vs. the back. (The arm rests can only be attached to the back.) So I wish that had been clearer up front, but otherwise it was okay.
Recommendations for assembly:
- To attach the wheels, apply firm, direct, straight-down pressure. I tried screwing them on at first but you just push. Make sure they go in the whole way like the picture shows.
- When they say to tighten the screws to only 60%, it's a helpful tip, because you can't fit the armrests on both the seat and chairback at the same time with the screws completely tightened. Just tighten them enough to fit the pieces on, then later you can tighten up the screws.
So far I find the chair to be very comfortable and I'm exceedingly happy with it. The lumbar support seems like it could potentially be a little chafy or scratchy, but I'll give the chair a chance before deciding if it's problematic or not. Like I said, I only got the chair today, so I can't speak much to its long-term comfort, durability, or longevity. But I was so impressed with how easy and straightforward they made the assembly that I had to write a review to show my appreciation.
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Reviewed in the United States on May 9, 2026
★★★★★ 3
It's okay
Color: Black
Appeared to be a super comfortable chair. Purchased for my mother to work from home and the material is apparently slightly itchy and the arm rest isn't quite comfortable. It was pretty simple to put together but it did take some time.
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Reviewed in the United States on June 11, 2026