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Description
New guidance on the use of GLP 1 based drugs in people with type 1 diabetes (T1D), due to be published later this year, will address the safety and optimal use of these medications This recent news from the Centers for Medicare & Medicaid Services (CMS) is another win for the treatment of obesity and related conditions. Starting July 1, 2026, CMS announced it will provide Mayo Clinic researchers have developed a genetic test that can help predict how people will respond to weight loss medications such as GLP 1s. The test estimates an individual's calories to satiation ( Trends in the Development of GLP 1 Receptor Agonists TL;DR: A 2026 meta analysis in Sleep and Breathing found that GLP 1 drugs, metabolic hormone medications involved in glucose, appetite, and weight regulation, were linked to fewer obstructive sleep apnea breathing events in
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4.5 ★★★★★
Based on 1519 reviews
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Product Reviews
★★★★★ 5
It did work
Size: 1-Pack (32 oz)
Sealed a small nail hole in a front tractor tire. Better than taking to shop for inside patch or making the 3x bigger for a rope patch.
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Reviewed in the United States on May 6, 2026
★★★★★ 5
Fixed a Bead Sealing Issue
Size: 1-Gallon (128 oz)
For traction in snow, I recently installed new "agricultural" style lugged front tires on a Simplicity garden tractor from around 1980. The tractor looks like it's survived a war, evidently having had a hard life as a workhorse owned by a school district.
The front rims are rusty, and I naively thought the beads of these thick tires would seal properly anyway. They didn't.
The jug of sealant ships with a valve core removal tool. Removing and reinstalling the cores is a piece of cake if you've never done it. I pumped a generous amount of the product into each tire and then did a few fast laps in a grassy paddock. It's a Kohler 19HP twin and it's a bit of a rocket. 😎 One tire sealed, the other didn't, and there was still a faint hiss. I added more product to that side and repeated the process. It seemed to hold. The next day that side was flat again, so I added more sealant and this time it held.
Based on this experience, I'd say that instead of strictly following what the instructions recommended as an amount per tire, keep adding product in increments until the tire holds air.
It's good stuff and it works. Will the tire self-heal if I puncture it? I don't know yet. It saved me the headache of having to remount these small tires or install tubes.
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Reviewed in the United States on May 24, 2026
★★★★★ 5
Stop wasting your money on green slime or Fix-A-Flat or any of the other tire sealant
Size: 1-Gallon (128 oz)
Flat out is by far the best product on the market to fix flat tires and prevent flat tires. This will be the second gallon jug that I purchased that stuff on everything. all of my landscape equipment has it in every tire. And to paint and even better picture for you I have a scag mower that is 20 years old The tires are probably 18 years old ugly as could be and would not hold air until I put the flat out in it it has been sitting now for over a year and every tire still has air That's how good the stuff is. Don't just buy one gallon by two cuz it will get used
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Reviewed in the United States on July 11, 2025
★★★★★ 5
John Deere 5x4 (gator)
Size: 4-Pack (128 oz), Size: 4-Pack (128 oz)
Excellent product. The John Deere 5x4 (Gator) in picture sat for ten years, the tires were flat, the front tire was the worse. To move this Gator from my neighbors place he had to load it on a trailer, he aired up the rear 4 tires but the front would air up and leak before he could move it. He put a make do wheel to get it moved to my place. shortly after unloading the rear 4 tires went flat. All were badly weathered. I read about a stop leak "FLATOUT" I ordered one bottle and put it in the front wheel and I aired it up, it held air for several hours. I called FLATOUT Support and told them I put 1/2 bottle in front tire and how it helped, He said it calls for a full bottle per tire so I added the rest of the FLATOUT. I bought four more bottles of FLATOUT and put those in all 4 tires, put air in and drove the unit a block. next day two tires were low so I finished putting FLATOUT in and aired the tires and drove two to three blocks. the weather snowed so I parked the Gator for two weeks, the tires never went flat. I checked the air pressure and had lost about 2-3 pounds, refilled with air and on a warm day drove the Gator about 2 miles. No flat tires. Note the front tire had a weathered crack 4 inches long where it sat folded for so many years and I saw where this product had sealed this leak and no air loss after two weeks of sitting.
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Reviewed in the United States on April 7, 2021
★★★★★ 5
Recommended
Works extremely well for tire patch repairs. Just be sure product is totally dry before applying patch on inner tube or interior of tubeless tire.
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Reviewed in the United States on January 25, 2026