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Description
Rig-I Recombinant Rabbit mAb (S-2293-22)Product Specification Host Rabbit Antigen Rig I Synonyms Antiviral innate immune response receptor RIG I; ATP dependent RNA helicase DDX58; DEAD box protein 58; RIG I like receptor 1 (RLR 1); RNA sensor RIG IImported; Retinoic acid inducible gene 1 protein (RIG 1); Retinoic acid inducible gene I protein (RIG I); Ddx58; Rigi Immunogen Recombinant Protein Location Cytoplasm Accession Q6Q899 Clone Number S 2293 22 Antibody Type Recombinant mAb Isotype
Product Specification
| Host | Rabbit |
| Antigen | Rig-I |
| Synonyms | Antiviral innate immune response receptor RIG-I; ATP-dependent RNA helicase DDX58; DEAD box protein 58; RIG-I-like receptor 1 (RLR-1); RNA sensor RIG-IImported; Retinoic acid-inducible gene 1 protein (RIG-1); Retinoic acid-inducible gene I protein (RIG-I); Ddx58; Rigi |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm |
| Accession | Q6Q899 |
| Clone Number | S-2293-22 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms |
| Positive Sample | RAW264.7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Ms |
Background
RIG-I（Retinoic acid-inducible gene I）is a key protein in the innate immune system that plays a crucial role in detecting viral infections. It is an intracellular pattern recognition receptor that primarily recognizes double-stranded RNA and 5′-triphosphate single-stranded RNA, which are often produced during viral replication. When RIG-I binds to these viral RNA molecules, it undergoes conformational changes and activates downstream signaling pathways, including the induction of type I interferons such as IFN-α and IFN-β. These interferons help to establish an antiviral state in infected and neighboring cells by upregulating the expression of various antiviral proteins. RIG-I is highly expressed in immune cells like dendritic cells and macrophages, as well as in many other cell types. Its function is essential for the early detection and response to RNA viruses, making it a vital component of the host's defense mechanism against viral infections.
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