E-Selectin/CD62E His Tag Protein, Cynomolgus
SKU: 73272109353

E-Selectin/CD62E His Tag Protein, Cynomolgus

Sale price$108.00 Regular price$120.00
Save 10%

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Jul 7 - Jul 12

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

E-Selectin/CD62E His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms LECAM2, ELAM1, Endothelial leukocyte adhesion molecule 1, ELAM 1, SELE, Selectin E, CD62 Antigen Like Family Member E, Endothelial Adhesion Molecule 1, Leukocyte Endothelial Cell Adhesion Molecule 2, CD62E Antigen, ESEL, ELAM, Leukocyte Endothelial Cell Adhesion Molecule 2 Accession XP_005539998. 2 Concentration 95% by SDS PAGE & SEC HPLC Amino Acid Sequence Trp22 Pro556 with His Tag at the C Terminus

Product Specification


Species Cynomolgus
Synonyms LECAM2, ELAM1, Endothelial leukocyte adhesion molecule 1, ELAM-1, SELE, Selectin E, CD62 Antigen-Like Family Member E, Endothelial Adhesion Molecule 1, Leukocyte-Endothelial Cell Adhesion Molecule 2, CD62E Antigen, ESEL, ELAM, Leukocyte Endothelial Cell Adhesion Molecule 2
Accession XP_005539998.2
Concentration >95% by SDS-PAGE & SEC-HPLC
Amino Acid Sequence

Trp22-Pro556 with His Tag at the C-Terminus

Expression System HEK293
Molecular Weight

90-110kDa (Reducing)

Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, 5% trehalose, PH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Liu ZJ, Tian R, An W, Zhuge Y, Li Y, Shao H, et al.. Identification ofE-selectin as a novel target for the regulation of post-natalneovascularization: implications for diabetic wound healing. Ann Surg. (2010)252:625–34.

Background

E-Selectin, officially known as Endothelial Leukocyte Adhesion Molecule-1 (ELAM-1) or CD62E, is a member of the Selectin family of cell surface glycoproteins with a molecular weight ranging from 107 to 115 kDa. This cell adhesion molecule plays a pivotal role in inflammation and neovascularization, particularly in wound healing and ischemic areas.
Upon tissue injury, the release of cytokines and chemokines, such as stromal cell-derived factor 1α (SDF-1α), triggers the local expression of membrane-bound E-Selectin on endothelial cells. Concurrently, it induces the expression of systemic reciprocal E-Selectin ligands on endothelial progenitor cells (EPCs) within the bone marrow, mediated by the C-X-C motif chemokine receptor 4 (CXCR4).
E-Selectin is transiently expressed on vascular endothelial cells in response to cytokines like IL-1 beta and TNF-alpha, peaking at 4 hours post-activation and decaying by 24 hours. This cell surface glycoprotein is integral to immune cell adhesion, specifically by interacting with SELPLG/PSGL1 on blood neutrophils, which facilitates their adhesion to cytokine-activated endothelium. E-Selectin may also contribute to capillary morphogenesis.
During inflammation, E-Selectin mediates the attachment of flowing leukocytes to the blood vessel wall by binding to E-Selectin ligands present on leukocytes. These initial interactions are dynamic, allowing leukocytes to roll along the vascular endothelium in the direction of blood flow. Subsequently, stronger interactions involving ICAM-1 and VCAM-1 lead to the extravasation of white blood cells through the blood vessel wall and into the extracellular matrix of surrounding tissues.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 73272109353

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.7 ★★★★★
Based on 2393 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
C
Verified Purchase
christy
Grantham, US
★★★★★ 5
It works!!!!
Size: 2 fl oz
This stuff works!!!!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 29, 2026
D
Verified Purchase
Dave Wright
Cuba, US
★★★★★ 5
STA-BIL Start Your Engines! Because Sometimes Engines Need a Pep Talk
Size: 2 fl oz
So, STA-BIL Start Your Engines! is basically that friend who shows up uninvited but actually saves the day. You know, the one who doesn’t ask questions and just gets your engine running when it’s feeling moody or sluggish. Does it work? Of course it does. Like, “put a little in your gas tank, say a quick prayer, and voila!” kind of work. Suddenly your car remembers how to start, and you feel like a mechanic genius without actually lifting a wrench. It’s simple, it’s reliable, and it doesn’t judge you for letting your gas sit around until it gets that “I don’t want to cooperate” attitude. Pros: Makes your engine start like it just had an espresso shot. Easy to use — even if you’re barely awake in the morning. No weird smells or smoke signals, just clean, smooth starting. Cons: Won’t fix your “I forgot to put gas in” problem. Sadly, can’t make your car drive itself to work (yet). You might start relying on it a little too much — hey, no judgment. Final Verdict: ⭐️⭐️⭐️⭐️⭐️ – 5 stars. If your engine is feeling lazy, this stuff just works. It’s like a pep talk in a bottle for your car. Highly recommended for anyone who’s ever cursed their ignition.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 17, 2025
N
Verified Purchase
Nobody
Carnegie, US
★★★★★ 5
GREAT PROPDUCT
Size: 2 fl oz
EXCELLENT
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 27, 2026
A
Verified Purchase
Amazon Customer
Bozeman, US
★★★★★ 4
Cleans Out Working Carburetors
Size: 2 fl oz
I recommend this product for engines that will in fact start but not run well. I highly recommend it for that specific purpose, which it is designed for. It cleans the inner workings of the carburetor. Of course, you will have a cleaner carburetor if you take it apart and clean it with proper tools and a proper carburetor cleaner. You spray it in the gas tank, start the engine, and let it run a bit. It will not start an engine with a totally plugged up carburetor. Nothing is going to do that. Nor is it a fuel stabilizer, as one previous reviewer seemed to think. Nor is it a product to be used to bring life back to stale gasoline, as another reviewer seemed to think. The only thing to do with stale gasoline is drain it out and pitch it. Nor is it a product to be used for cleaning a carburetor you have taken apart to clean. You should use a proper carburetor cleaner for that purpose. I've given it four stars because it cleans out mildly plugged up carbs. It is not a miracle solution for really neglected carbs as the name suggests.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 12, 2020
R
Verified Purchase
Ray
West Palm Beach, US
★★★★★ 5
Helps fixing small engines
Size: 2 fl oz
⭐⭐⭐⭐⭐⭐⭐
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 16, 2026

recommand products