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Description
Biotin Mouse Anti-Rat CD62L Antibody (S-R605)Product Specification Host Mouse Antigen CD62L Synonyms L selectin; CD62 antigen like family member L; Leukocyte adhesion molecule 1 (LAM 1); Leukocyte endothelial cell adhesion molecule 1 (LECAM1); Lymph node homing receptor; Lymphocyte antigen 22 (Ly 22); Lymphocyte surface MEL 14 antigen; Lnhr; Ly 22; Sell Location Cell membrane Accession P30836 Clone Number S R605 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Rt Positive Sample
Product Specification
| Host | Mouse |
| Antigen | CD62L |
| Synonyms | L-selectin; CD62 antigen-like family member L; Leukocyte adhesion molecule 1 (LAM-1); Leukocyte-endothelial cell adhesion molecule 1 (LECAM1); Lymph node homing receptor; Lymphocyte antigen 22 (Ly-22); Lymphocyte surface MEL-14 antigen; Lnhr; Ly-22; Sell |
| Location | Cell membrane |
| Accession | P30836 |
| Clone Number | S-R605 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | SD Rat splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Rt |
Background
CD62L, also known as L-selectin, is a type of adhesion molecule belonging to the selectin family and is primarily expressed on the surface of leukocytes, including T cells, B cells, and natural killer cells. It plays a crucial role in leukocyte homing and immune cell localization, facilitating the migration of T and B cells from the bloodstream into lymphoid tissues. In the immune response, CD62L mediates the initial adhesion and rolling of leukocytes on endothelial cells, promoting their movement to inflamed sites. Additionally, it serves as a phenotypic marker for central memory T cells (Tcm), which have high CD62L expression and can rapidly respond to antigen re-exposure. CD62L is also involved in the regulation of immune cell distribution and has potential applications in cancer immunotherapy, such as enhancing T cell infiltration into the tumor microenvironment.
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Exchange/Return Notes
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