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Description
HDAC1 Recombinant Rabbit mAb (SDT-310-72)Product Specification Host Rabbit Antigen HDAC1 Synonyms Histone deacetylase 1, HD1, Protein deacetylase HDAC1 Immunogen Synthetic Peptide Location Nucleus Accession Q13547 Clone Number SDT 310 72 Antibody Type Recombinant mAb Application WB, IHC P, ICC, ICFCM, IP Reactivity Hu, Ms, Rt Predicted Reactivity Bv Purification Protein A Concentration 0. 05 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | HDAC1 |
| Synonyms | Histone deacetylase 1, HD1, Protein deacetylase HDAC1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q13547 |
| Clone Number | SDT-310-72 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, ICFCM, IP |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.05 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied. |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | |
| IHC-P | 1:200 | |
| ICC | 1:50 | |
| ICFCM | 1:50 | |
| IP | 1:25 |
Background
HDAC family has four subclasses including I, II, III and IV. Histone deacetylase 1 (HDAC1) is a unique member of the classes I HDACs that has been shown to be involved in gene transcription, transcriptional regulation, cell cycle progression and developmental events by controlling both enzyme activity and epigenetics of key proteins [PMID: 16289629]. HDAC1 is the most abundant member of the class I HDACs in pulmonary endothelial cells [PMID: 34264338], regulating the enzymatic activity and epigenetics of key proteins to adapt to external stimuli. It can efficiently decrotonylate this relatively less abundant histone modification [PMID: 29317660].
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Exchange/Return Notes
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4.7 ★★★★★
Based on 22 reviews
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Product Reviews
★★★★★ 4
My Hero pup is super happy with it
Color: Large - Billy the Beast Monster
I was super excited to order this and had waited some time to do so. I wanted Big Billy The Beast Monster in large Green, he’s an awesome looking guy. My Golden Retriever was all over me while I was up packaging Him and his tail was in helicopter mode. He was so excited to have it and carried it around the house everywhere we went, he’s laying on me with his head in my lap and Billy’s right next to him. Reason for buying it? Well he loves plushies but there are not many available out there that can stand up to this 80 pound chew monster so I have to keep him on harder stuff, 2 of which are the cheapest toy skull and crosses in orange and blue from a cheap outlet site but he loves them. Orange was first then when we pulled out the blue one he had a aha moment. Now with Billy he was on a whole new level of excitement, I’ve never seen him this excited over a toy, he can’t stop carrying it with him everywhere and showing it off to the other pups I have, there’s no growling or resource guarding but he definitely won’t want to share and that’s of because I always take away any plushies that he gets to because he is serious about chewing. This being made with Kevlar gave me hopes of longevity but he had the ears and the end of 1 hand chewed off in under 2 hours, am I disappointed…yea a little but he has gotten so much joy out of it that it’s made me really happy to have bought it anyway, see he’s my Service Dog so he spends a lot of time being so serious and working that he needs any outlet for spending energy possible and he’s so happy with it that it makes me happy. As I’m writing this he’s asleep with his head in my lap and Billy right next to him looking very tired and happy and that my friends is worth all the beans in the world.
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Reviewed in the United States on May 4, 2026
★★★★★ 5
Survives agressiveness
Color: Large - Billy the Beast Monster
This toy is absolutely for aggressive chewers,my yorkies usually have their stuffed animals torn apart within a day,been a week and not 1 rip! Very happy with it and worth the money!!!
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Reviewed in the United States on May 29, 2026
★★★★★ 4
Great except for one small flaw
Color: Regular - Beak, Color: Regular - Beak
Our dog likes to get at the juicy innards of every toy we buy him. We tried this one as it promised to be "bullet proof". It lasted about a week which in fairness is 6.5 days longer than most of the toys we buy last. He ripped off the wings which was to be expected and not an issue. It took him another 6 days to finally locate a weak point and break in. It appears that the tag is not made of kevlar but merely sewed on. I guess it would be better if they had just sewed it on top but they made it part of the overall structural integrity. This provided a small area of weakness which our dog located and proceeded to exploit. It's like having the death star but installing a small thermal exhaust port that allows for access to the very core of the station. Makes little sense. Overall I am pleased with the overall sturdiness but in the end this toy had a small design flaw that my dog was able to locate and exploit in his neverending quest to gain access to and eat polyester fiber stuffing
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Reviewed in the United States on March 6, 2026
★★★★★ 5
STRONG AS A MONSTER (albeit a cute one)
Color: Large - Billy the Beast Monster, Color: Large - Billy the Beast Monster
My aggressive chewer ate the adorable monster's ear off on the first day, but who cares? The body of the monster has been indestructible so far (one week). My 7 month old pup cbews it for a good 10-15 minutes at a time several times per day. Great quality product and outlasting all the other toys I bought (which she destroyed in 10 minutes - even the ones rated "Level 4 toughness" from Walmart. I think it's hilarious in my photo that the monster's expression perfectly shows his disappointment about missing an ear, LOL.
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Reviewed in the United States on June 3, 2026
★★★★★ 5
King has met his match.
Color: Large - Billy the Beast Monster
I received my dog's toy this evening when I place the toy on the ground my dog King went crazy. He is a one-year-old Pitbull and love to tackle any toy he believes he can't take down, but Mr King has met his match with this toy. He was using all of his bite force to demolish the toy but the toy actually has worn him out. He ran around my yard for about 30 minutes with the toy in his mouth producing the squeaking sound from the toy as well. Hold up the toy is totally filthy with dirt almost covering the entire green and yellow belly of the toy. I have brought king mini toys in the last couple of months and this is the best toy that holds up to his energy level. I tried to retrieve the toy and place it in his dog house because it is far beyond his bedtime, but he wanted to play catch me if You can with my new toy. This is a great toy for those big energetic dogs that love to take their aggression out on maybe some furniture or perhaps that favorite shoe you do not want them to chew on. I am totally sold on this toy I brought from the seller who placed the items on the Amazon site. I plan on purchasing a another toy from the buyer to keep King energy at a low level if I can. I just checked on my dog and he actually has taken the toy with him inside of his dog house and now the toy is snugged under his left paw. I'm one of those smart owners I'm not going to even try to take it from him tonight but hopefully in the next week I can sneak it from him and it may be perhaps wash it. I did this item AA Plus
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Reviewed in the United States on January 31, 2026
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