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Description
STUP1/CHIP His Tag Protein, HumanProduct Specification Species Human Synonyms CHIP, PP1131, STUB1, E3 ubiquitin protein ligase CHIP, Antigen NY CO 7 Accession Q9UNE7 Amino Acid Sequence Ser23 Tyr303 with His Tag at the N Terminus Expression System E. coli Molecular Weight 33 43kDa (Reducing) Purity 95% by SDS PAGE,> 90% by HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Liquid Storage Buffer 50mM Tris, 150mM NaCl, pH7. 5, 1mM DTT, 10%Glycerol Stability & Storage Stable
Product Specification
| Species | Human |
| Synonyms | CHIP, PP1131, STUB1, E3 ubiquitin-protein ligase CHIP, Antigen NY-CO-7 |
| Accession | Q9UNE7 |
| Amino Acid Sequence | Ser23-Tyr303 with His Tag at the N-Terminus |
| Expression System | E.coli |
| Molecular Weight | 33-43kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE,> 90% by HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | 50mM Tris, 150mM NaCl, pH7.5, 1mM DTT, 10%Glycerol |
| Stability & Storage |
Stable for 12 months upon stored at -80℃ from the date of receipt. And avoid repeated freeze-thaws cycles. |
| Reference | 1. Ballinger, C.A., et al. (1999). Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Molecular and Cellular Biology, 19(6), 4535-4545. |
Background
STUB1 (STIP1 Homology and U-Box Containing Protein 1), commonly known as CHIP (C-terminus of Hsc70 Interacting Protein), is a crucial dual-function protein in cellular proteostasis. It serves as both a co-chaperone and an E3 ubiquitin ligase. As a co-chaperone, it binds to the molecular chaperones Hsp70/Hsc70 and Hsp90 via its N-terminal tetratricopeptide repeat (TPR) domain, assisting in client protein folding and stabilization. Its central role lies in its C-terminal U-box domain, which confers E3 ubiquitin ligase activity. This unique combination allows CHIP to ubiquitinate misfolded or damaged client proteins that are delivered by the chaperones, thereby targeting them for proteasomal degradation. It is a central component of the Protein Quality Control (PQC) system, clearing toxic protein aggregates and maintaining proteome integrity.Dysregulation of CHIP function is linked to various human diseases. Loss-of-function mutations or reduced expression are associated with neurodegenerative disorders (e.g., spinocerebellar ataxia, Alzheimer's, Parkinson's) due to defective clearance of pathogenic proteins like tau and α-synuclein. Conversely, its role in degrading oncogenic clients (e.g., HER2, c-Myc) positions it as a potential tumor suppressor in certain cancers. It also plays key roles in aging, cardiac function, and immune responses, making it a significant therapeutic target.
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4.9 ★★★★★
Based on 6 reviews
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Product Reviews
★★★★★ 5
Great Product, Works as Advertised
Flavor Name: Unflavored, Size: 1.46 Pound (Pack of 1)
This product works exactly as described. It makes BM's smoother and gentler. I personally use the unflavored, no sweeteners added version, and honestly, it does not taste very good, but I feel that the results are worth it, and I do not like adding extra sweeteners or flavorings to my diet. I have used this product for many years and have found that about 1 1/2 to 2 tbsps in 12 ounces of water works the best for me. You will need to experiment a bit to find the ratio that works best for you. I recommend that you start on the low side and gradually increase the amount of Metamucil as needed.
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Reviewed in the United States on March 26, 2026
★★★★★ 5
Healthy, Effective, and great when mixed with Splenda and Koolaid mix. The best of many options I've tried.
Flavor Name: Unflavored, Size: 1.46 Pound (Pack of 1)
I've sampled a few different varieties of fiber supplements, including both Benefiber and off-brands, and I found that Metamucil provided the most fiber in the least offensive beverage. Compared to the other brands, this stuff is smoother textured, and goes down easier, as a sort of happy medium between the grittier supplements and the thicker ones.
What about effectiveness? I have apocalyptic IBS, and since starting to take this stuff regularly (one giant glass every morning and evening), my BMs have been much more regular, and more manageable. Flare-ups happen less, and it even seems to do a decent job when taken with meals of cutting the hit to my stomach and gut. I tend to take more than the recommended amount, with an even larger serving of water, as I feel like it helps me stay hydrated and full throughout the day.
I started taking the classic orange Metamucil, but although I really liked the superior flavor (rather like Orange Tang) it packed several times more sugar in each serving than fiber, so while it was great for digestive health, the overall health impact was too negative. I also sampled the sugar-free berry flavors, but found that, although it was ostensibly healthier, the flavor wasn't great, and in addition it suffered from the aspartame aftertaste and further effects (Aspartame gives me headaches). So this was a dilemma for me. What to do? I actually wrote to Metamucil about it, and they recommended this product. The downside is that it comes with absolutely no flavor, so you need to provide your own in order to mask the texture (I wouldn't dream of trying to mix this in plain water--yuck!) The upside is they pack 100+ servings into a container, and you really are free to blend it into whatever suits your fancy. Obviously if you mix it with something like orange juice, then you're already negating the benefits of this stuff over the sugary orange flavor, but I've personally found a much better way.
I like to mix this stuff with Kool-aid mix and Splenda (Sucralose) sweetener. I buy a ton of Splenda and kool-aid as it mixes up tasting sweet, like sugar, but without the calories or aftertaste. You can dump a spoonful of this stuff into a glass of splenda-koolaid, or just dump 8 servings worth of this stuff in with a packet of koolaid powder and a cup of splenda, and then just mix it up and spoon it into water as needed. Better tasting, sugar-free and packed with good useful fiber.
EDIT: I wish I could subscribe to this stuff. Price of splenda has gone up, but I've figured out thatyou can just dump 7 packets of koolaid mix and 7 dashes of sucralose into a container of this and shake it up.
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Reviewed in the United States on February 26, 2015
★★★★★ 5
#1 for #2's
Flavor Name: Unflavored, Size: 1.46 Pound (Pack of 1)
I like the lack of sweeteners and flavor. I just want the stuff that helps me poop. There is some citric acid in it (no idea why) which gives it a mildly acidic taste. Other than that, it does the trick.
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Reviewed in the United States on March 23, 2026
★★★★★ 5
Good Stuff
Flavor Name: Unflavored, Size: 1.46 Pound (Pack of 1)
If you need more fiber in your diet, you need this. The price is right, it works very well and keeps me regular. I use this instead of the gummies or capsules. That's because you MUST put in in fluid, and hydration is SO important when using a psyllium product as it causes water to be absorbed very quickly once it is ingested, and you don't want to dehydrate! Mixes very well in water and has little to no taste whatsoever. Stay regular, stay hydrated and stay well.
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Reviewed in the United States on April 14, 2026
★★★★★ 4
Works well, but is now too expensive...
Flavor Name: Unflavored, Size: 1.46 Pound (Pack of 1)
The "No added sweeteners" has been my go-to version of Metamucil, but I'm giving it 4 stars and moving on to another brand as the price is over $35 which is too much imo...
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Reviewed in the United States on October 15, 2025
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