SKU: 80450254112

Protopic

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Description

ProtopicProtopic Description Protopic is a cream used on the skin to treat inflammation, such as perioral dermatitis. It blocks calcineurin, a protein that triggers your body's inflammatory cells, helping to reduce inflammation. Apply it twice daily until the affected area improves, then switch to twice a week to maintain your condition. Essential Information What is Protopic? Protopic ointment includes tacrolimus, which helps to lessen inflammation and

Protopic Description
Protopic is a cream used on the skin to treat inflammation, such as perioral dermatitis.
It blocks calcineurin, a protein that triggers your body's inflammatory cells, helping to reduce inflammation.
Apply it twice daily until the affected area improves, then switch to twice a week to maintain your condition.

What is Protopic?

Protopic ointment includes tacrolimus, which helps to lessen inflammation and itching. It's used to treat different types of dermatitis (skin irritation) when the condition is believed to be caused by an immune response.

Perioral dermatitis appears as a red rash around the mouth, often accompanied by itchiness and spots. The exact cause isn't completely known, but some believe that inflammation of the hair follicles might lead to spots forming around the mouth. Although topical steroids are commonly used to treat this condition, overuse can cause dermatitis when you stop using them. Other possible causes include hormonal changes, taking oral contraceptives, and fungal infections.

How does Protopic work?

Protopic contains tacrolimus, which is an immunomodulating agent that influences your immune system. When you apply it to your skin, it blocks calcineurin, which helps reduce inflammatory substances like mast cells, cytokines IL-2, and TNF-alpha. Consequently,

How is Protopic different from other treatments for perioral dermatitis?

Protopic is a type of immunosuppressant. It works by dampening the immune response, which helps to lessen inflammation and itching. Elidel is a similar medication to Protopic. It contains pimecrolimus, which also helps to reduce inflammation and is used to treat dermatitis.

If the affected area is severely infected, your doctor might prescribe antibiotics such as Lymecycline for a few weeks. This helps stop the bacteria causing the infection, which can ease itching and also reduce inflammation and spots.

How well does Protopic work for perioral dermatitis?

Tacrolimus has been shown to effectively treat dermatitis. A study from 2000 revealed that patients using 0.1% tacrolimus twice a day experienced noticeable improvements within a week (54%), with even better results after 6 months (81%) and a year (86%).

Moreover, when comparing tacrolimus to topical corticosteroids for treating atopic dermatitis, 71.6% of patients using tacrolimus showed more improvement within 3 months, compared to 50.8% of those using a steroid.

Important Information

Protopic isn't right for everyone, and there are a few things you should know when using it.

Here's all the official information on it. If anything isn't clear, just let our clinician know, and they can discuss it with you.

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SKU: 80450254112

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4.9 ★★★★★
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Dee97
Bozeman, US
★★★★★ 5
A great toy for any dog!
Style: Small Ball, Size: 1 Count, Style: Small Ball, Size: 1 Count
The Hartz Duraplay ball is great! My 4 1/2 yr. old Pug has never liked playing with them before. He has gone crazy for this ball. He has no trouble grabbing it with is mouth. He ever gets it to squeak with his feet. I think it’s a great dog toy. Excellent!
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Reviewed in the United States on May 30, 2026
C
Verified Purchase
Cassie
Grantham, US
★★★★★ 5
Great Value and very durable
Style: Small Ball, Size: 1 Count
Very durable! We have purchased this for our new lab puppy. Highly recommend them. We have bought them before for our retrievers and it has been one of the longest lasting toys they own. Which says a lot because toys get torn up fast in our house. Definitely a good value and the material is easy on their teeth. Also it keeps ours busy for a while.
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Reviewed in the United States on June 11, 2026
A
Verified Purchase
Anthony Ginnetti
Omaha, US
★★★★★ 5
Great product! Durable, chewable, awesomeness!
Color: Grilled color, Color: Grilled color
Very well made and durable. My dog hasn't left them alone since i opened them. Hes been at it for about 45 minutes straight now! Lol. He's an avid chewer. He will chew thru and fabric or cloth toys in less then a day. But these are what he really likes because they take time to chew apart. The shapes, are great, because one he props up with his paws and chews and it seems like it's easy to grip for him. Thru are hard so if you have hard floors it can get a bit noisy when he drops them. Over all this is a great product. Safe, chewable, long lasting, fun shape looks real to him (i think lol), Me and my dog Lucky are both happy with his new toys!
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Reviewed in the United States on March 27, 2026
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Verified Purchase
Jackster
Houston, US
★★★★★ 5
Recommend for very heavy chewers
Color: Grilled color
My aggressive chewers love these! It’s been a few weeks and still in one piece and man they chew them for hours on end.
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Reviewed in the United States on May 26, 2026
N
Verified Purchase
Nicholas Kiefer
West Palm Beach, US
★★★★★ 5
Amazingly great product!
Color: Grilled color
I’m not just saying this, ok, this is not hyperbole: this is THE best nylon bone for chewing that I have ever purchased. And you get TWO of them for relatively less expensive than most chew toys give you one! I have 2 golden retrievers, and if you know goldens, you know that they are some of the most relentless and powerful chewers around. So I can’t give them almost any toy other than rubber stuff or it will be destroyed in a period of time that doesn’t make it worth it. One of them even figured out how to destroy a supposedly indestructible toy made out of kevlar! She was able to get into it through the seam, which is not kevlar ha ha. Anyway, I digress; I never even considered nylon chews because they suck! Usually. Usually my dogs in the past have lost interest with them in less than a day. I took a chance on these mainly because of the novel shapes, the fact that they give you two, and the low price. Both my goldens LOVE these! Not just for one day, but going on weeks now! I don’t know if it’s the flavor or what, but I will see them gnawing on one of them at some point every day. And they CAN’T destroy them (I knew nylon was good for that, but it was the “who cares” attitude of my previous dogs toward nylon that kept me away). Both the “ribs” and “steak” (quite clever) are a bit worn on the edges now, but they look like they will be around for years. You can’t go wrong with this product (unless for some reason your dog does not like the flavor, but the flavor seems to be what draws my dogs to them). I highly recommend this (these) as the most cost-effective chew toy I’ve ever purchased.
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Reviewed in the United States on November 1, 2025

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